Industrial PhD position in the Innovative Training Network UBIMOTIF

Within the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 860517, Beactica Therapeutics AB is offering a 36-month PhD position for an Early Stage Researcher (ESR) in in the area of biochemistry.

The UBIMOTIF consortium includes 13 research groups and 6 partners from 10 European countries and is a joint training and research program with focus on identification, characterization and exploitation of short linear motifs in the ubiquitin system.

Visit www.ubimotif.ku.dk for more information.

Vacant position: Identification of potential drug leads targeting ubiquitin ligases and DUBs

Host: Beactica Therapeutics AB
Industrial supervisor: Dr. Ulf Bremberg (Beactica)
Academic supervisor: Prof. Helena Danielson (Uppsala University)

Synopsis

The projects will be focused on targeting complex protein-protein interactions using biophysical approaches and SLiMs.

Objectives

  • Development of strategies for identifying hits and progressable leads targeting several classes of ubiquitin ligases and deubiquitylating enzymes (DUBs).
  • Adaptation of Beactica’s SPR-based platform for peptide-based lead discovery using SLiMs.

The ESR is planned to carry out two secondments of 2-4 months each.

Qualifications

Required diploma: MSc degree in Biochemistry, Biophysics or related Molecular Life Science degree. Required expertise: Experience in biochemical and/or biophysical characterization of proteins. The candidate has a strong background in biochemistry or biophysics, and has experience in variety of methods for producing proteins and characterizing their structural and functional properties. Recommended expertise: Use of advanced biophysical instruments and development of new biochemical and biophysical assays. An interest in computer-aided drug design and mathematical modelling and statistical analysis of biochemical data would be an advantage. The candidate needs to be able to discuss and develop methods in collaboration with the other students in the consortium.

Special requirements

  • Applicants can be of any nationality.
  • Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network training.
  • Applicants must be eligible to enroll in the PhD programme in biochemistry at the department of Chemistry- BMC, Uppsala University. I.e, you must have at least 240 credits (hp), or an equivalent basic university education, with at least 90 credits in chemistry and 60 credits at the advanced level in the specialization subject.
  • Being a PhD student in an ITN includes a considerable amount of travelling including participation in meetings and workshops and stays of periods of a few months outside the host laboratory. Therefore, a requirement is the willingness to travel and stay abroad.

Candidates will be required to meet the Marie Skłodowska-Curie Early Stage Researcher eligibility criteria:

Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in Sweden for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account. The earliest possible recruitment date is 1 March 2020.

Early Stage Researcher (ESR) criteria: ESRs must, at the date of recruitment by the host organization, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Full-Time Equivalent Research Experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited, even if a doctorate was never started or envisaged).

You will only be considered for the position if you fulfill (and can prove so) the eligibility criteria.

We offer

  • The opportunity to conduct cutting-edge research and access to a network of leading researchers in the field
  • Participation in research-specific, complementary and soft skills training that involve both the academic and industry sectors.
  • Appointment for a period of 36 months
  • Competitive salary, which is adjusted for their host country.
  • Mobility allowance and a family allowance (where applicable) as part of the employment package.

Local HR and application process

Please send your application to Helena.Danielson@beactica.com

Deadline for applications is 3 January 2020.

All applications must include:

  • CV
  • Cover letter that describes the applicants’ motivation to apply (max. 1 page)
  • Relevant diplomas
  • References